RGS3（regulator of G protein signaling 3），癌症关联基因，基因ID：5998，该基因编码G蛋白信号（RGS）家族调控因子的一个成员该蛋白是一种GTPase激活蛋白，可抑制G蛋白介导的信号转导。选择性剪接和选择性启动子的使用导致编码不同亚型的多个转录变体。长亚型主要是胞浆和质膜，与wnt信号和上皮-间质转化有关，而短n-末端截短亚型可以是核的。[由RefSeq提供，2013年1月]This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition， while shorter N-terminally-truncated isoforms can be nuclear. [provided by RefSeq， Jan 2013]。