ADH1C（alcohol dehydrogenase 1C (class I)， gamma polypeptide），癌症关联基因，基因ID：126，这个基因编码第一类醇脱氢酶，γ亚单位，是醇脱氢酶家族的一员。这种酶家族的成员代谢多种底物，包括乙醇、视黄醇、其他脂肪醇、脂肪醇和脂质过氧化产物。Ⅰ类醇脱氢酶由α、β和γ亚基的多个同源异构体和异二聚体组成，对乙醇氧化为乙醛具有高活性，因此在乙醇分解代谢中起重要作用。编码α、β和γ亚单位的三个基因以基因簇的形式排列在基因组片段中ADH1C多态性与酒精依赖性之间的关联尚未建立。[由RefSeq提供，2019年9月]This gene encodes class I alcohol dehydrogenase， gamma subunit， which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates， including ethanol， retinol， other aliphatic alcohols， hydroxysteroids， and lipid peroxidation products. Class I alcohol dehydrogenase， consisting of several homo- and heterodimers of alpha， beta， and gamma subunits， exhibits high activity for ethanol oxidation to acetaldehyde， thus playing a major role in ethanol catabolism. Three genes encoding alpha， beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. An association between ADH1C polym。