BAK1（BCL2 antagonist/killer 1），癌症关联基因，基因ID：578，该基因编码的蛋白属于BCL2蛋白家族bcl2家族成员形成寡聚体或异二聚体，作为抗或促凋亡的调节因子，参与多种细胞活动。该蛋白定位于线粒体，具有诱导细胞凋亡的功能。它与线粒体电压依赖性负离子通道的开放相互作用，加速线粒体电压依赖性负离子通道的开放，导致细胞膜电位的丧失和细胞色素c的释放，并与细胞应激后的抑癌基因p53相互作用。[由RefSeq提供，2008年7月]The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria， and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel， which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq， Jul 2008]。