TSN(translin),癌症关联基因,基因ID:7247,该基因编码一种DNA结合蛋白,该蛋白在染色体易位的断点处特异识别保守的靶序列易位蛋白多肽形成一个多聚体结构,负责其DNA结合活性重组相关的基序和易位结合位点存在于重组热点,可作为易位融合基因断点的标志。这些结合活性可能在淋巴肿瘤染色体易位中起重要作用由该基因编码的蛋白质与转译相关蛋白X复合时,也形成一种镁离子依赖性内核糖核酸酶,促进RNA诱导的沉默复合物(RISC)激活选择性剪接导致多个转录变体[由RefSeq提供,2012年5月]This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced s。