RBL1（RB transcriptional corepressor like 1），癌症关联基因，基因ID：5933，该基因编码的蛋白序列相似，可能与视网膜母细胞瘤1（RB1）基因的产物功能相似rb1基因产物是一种肿瘤抑制蛋白，似乎参与细胞周期的调控，因为它在s-m期转化时磷酸化，在细胞周期的g1期去磷酸化。rb1蛋白和该基因产物均能与腺病毒e1a蛋白和sv40大t抗原形成复合物，sv40大t抗原仅与每个蛋白的未磷酸化形式结合。此外，两种蛋白都能抑制启动子中含有E2F结合位点的细胞周期基因的转录。由于其序列和生化特性与rb1蛋白相似，因此认为该基因编码的蛋白也可能是一种抑癌基因。已经发现了两个编码不同亚型的转录变体。[由RefSeq提供，2008年7月]The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation， as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen， with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition， both proteins can inhibit the transcription。