PTPRS(protein tyrosine phosphatase receptor type S),癌症关联基因,基因ID:5802,该基因编码的蛋白是蛋白酪氨酸磷酸酶(ptp)家族的一员。众所周知,ptps是调节细胞生长、分化、有丝分裂周期和癌基因转化等多种细胞过程的信号分子。该ptp包含一个胞外区、一个跨膜段和两个串联胞浆内催化结构域,因此代表一种受体型ptp。该蛋白的胞外区域由多个ig样结构域和纤维粘连蛋白iii型结构域组成。对小鼠相似基因的研究表明,ptp可能参与了胚胎发生过程中的细胞-细胞相互作用、原发性轴突形成和轴突引导。这种ptp还与成人神经修复的分子调控有关。已经报道了四种选择性剪接的转录变体,它们编码不同的蛋白质。[由RefSeq提供,2008年7月]The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may。