FGF12（fibroblast growth factor 12），癌症关联基因，基因ID：2257，该基因编码的蛋白是成纤维细胞生长因子（fgf）家族的一员。fgf家族成员具有广泛的有丝分裂和细胞存活活性，参与多种生物学过程，包括胚胎发育、细胞生长、形态发生、组织修复、肿瘤生长和侵袭等。这种生长因子缺乏存在于fgf家族大多数成员中的n-末端信号序列，但它含有已被证明作为核定位信号的碱基残基簇。当转染到哺乳动物细胞中时，这种蛋白质在细胞核中积累，但不分泌。这个基因的具体功能尚未确定。报道了两种编码不同亚型的选择性剪接转录变体。[由RefSeq提供，2008年7月]The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities， and are involved in a variety of biological processes， including embryonic development， cell growth， morphogenesis， tissue repair， tumor growth， and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members， but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells， this protein accumulated in the nucleus， but was not secreted. The specific function of th。